Operated by the Novartis Institute of Biomedical Research, and the results of the first ISS National Lab Rodent Research Mission (RR-1), provided a quick model of disease to study the mechanism behind the disease and testing of scientists in research. And new treatments.
RR-1 mission aims to validate Rodent Research hardware system on ISS. And researchers from Novartis Institute of Biomedical Research - Research branch of Novartis, America's premier pharmaceutical company, has published the findings from the first research on rodent research on International Space Station (ISS). This investigation, Rodent Research (RR-1), has both services to recognize the Rodent Research hardware system on ISS, and to detect the molecular basis of skeletal muscle atrophy in microbiology.
Scientists have found the human for more than 100 years In health studies, rodents have used rodents as model organisms. In the 1950s, scientists studied the effects of Spaceflight on human health. Researchers from Novartis used the two groups of rats to assess the muscle changes in the hind limb muscles of the rats coming in contact with microbiology: muscle finger finger 1 ( MURF-1) A group of genes deficient mice- It is believed that it plays a role in triggering muscles to ruin- and A group of wild-type mice with the general expression of the MuRF-1 gene.
While researching the results of two groups, the research team examined the changes in the size of the muscles and muscle fibers as well as the changes in the protein and gene expression. Space-based rodent research made a significant turning point in 2014 with the introduction of the Rodent Research Hardware System on ISS, which opened the door for long-term rodent studies in space to advance research that would benefit human health back to Earth.
After the successful RR-1 mission, Novartis focused on the muscle trophy in the ISS National Lab Additional rodent research investigation. In an investigation launched in December 2017, Novartis partnered with the Houston Methodist Research Institute and Nanomedical Systems, a transplant drug for a muscle waster drug using a rodent model with microbiology-induced muscle trophy. To test delivery system, done. Such drug delivery systems avoid the need for daily injection and can turn into a commercial product in the future.